Tumor & Cancer Immunology and Pediatric-oncology 2022

Tumorigenesis

Tumorigenesis focuses on the multistep process of tumor Development, the critical progression of which is dependent on sequential accumulation of mutations within tissue cells, only a relatively small subset of which is crucial for malignant transformation, driven by the well-known pathways of tumorigenesis (growth signal self-sufficiency; anti-growth signal insensitivity; apoptosis evasion; unbound replicative potential; sustained angiogenesis; and tissue invasion and [potential metastasis). Tumorigenesis depends on carcinogenesis, but not vice versa, and when we focus on carcinogenesis, our scope rests predominantly with mutation or epimutation acquisition, while when we focus on tumorigenesis, our scope is on the multistep progress of mutated cells in tumor development.