Samir Mehndiratta
Taipei Medical University, Taiwan
Title: Indole-3-ethylsulfamoylphenylacrylamides with Potent Anti-proliferative and Antiangiogenic Activities
Biography
Biography: Samir Mehndiratta
Abstract
Histone deacetylases (HDACs) display multifaceted functions by coordinating the interaction of signal pathways with chromatin structure remodeling and thus play an important role during malignancy progression. HDAC inhibition shows promise as a new strategy for cancer therapy and four HDAC inhibitors have been approved. We have synthesized a PXD101-LBH589 core model based series of potent indole-3-ethyl sulfomoylphenylacrylamides as potent inhibitors of HDACs, developed the SAR and evaluated them for their anti-cancer and anti-angiogenic effects.